Aging theories, Using a novel biological aging clock, UCLA researchers find obesity accelerates aging of the liver

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The patterns of the figures provides a microscopic view of liver cells from lean left figure and obese subjects right figurerespectively.

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This finding could explain the early onset of many age-related diseases, including liver cancer, in obese subjects Although it had long been suspected that obesity ages a person faster, it hadn't been possible to prove the theory, said study first author Steve Aging aging theories, a professor of human genetics at the David Geffen School of Medicine at UCLA and a professor of biostatistics at the UCLA Fielding School of Public Health.

Using the epigenetic clock Horvath developed last year, he and Jochen Hampe from the University Hospital Dresden showed that carrying excessive weight can negatively impact select human tissues.

Horvath's aging clock uses a previously unknown time-keeping mechanism in the body to accurately gauge the age of diverse human organs, tissues and cell types.

What we do not know Free radicals are unstable atoms that can damage cells, causing illness and aging. Free radicals are linked to aging and a host of diseases, but little is known about their role in human health, or how to prevent them from making people sick. What are free radicals? Free radicals are thought to be responsible for age-related changes in appearance, such as wrinkles and gray hair.

He and his collaborators focused on a naturally occurring process called methylation, a chemical modification of aging theories DNA molecule. Horvath used this epigenetic clock to measure the biological age of several tissues.

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The aging clock proved accurate in matching biological to chronological age in lean subjects. But liver tissues from obese subjects tended to have a higher biological age than expected.

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In this study, Horvath looked at almost human tissue aging theories, including liver samples, to study the relationship between epigenetic age acceleration and body weight. While obesity doesn't affect the epigenetic age of fat, muscle or blood tissue, he and his collaborators found that, on average, the epigenetic age of the liver increased by 3. For example, a woman who is 5 szemtapasz gyerekeknek 5 and weighs pounds has a BMI of A woman the same height but weighing pounds would have a body mass index of Her liver would be about three years older than the woman who weighed pounds, the study found.

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Going forward, Horvath and his team want to determine if the premature epigenetic aging of liver tissue in obese people can be prevented to possibly reduce their risk of diabetes and liver cancer. They plan to work on models that allow them to dissect the exact molecular mechanisms behind this aging process - which is not known at this point - in order to find the right targets for therapy and prevention.

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